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Azithromycin was the first of the azalides and was designed to improve the stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Azithromycin is a long-acting macrolide antibiotic structurally related to erythromycin A (EA), having a methyl-substituted nitrogen at position 9a in the aglycone ring.Azithromycin belongs to broad-spectrum antibiotics and is the second-generation antibiotic of macrolides. The main effects are respiratory tract, skin and soft tissue infections caused by sensitive bacteria and chlamydia infectious diseases. It has a good therapeutic effect on acute bronchial infections caused by influenza bacteria, pneumococci, and Moraxella catarrhalis, as well as chronic obstructive pulmonary disease with pneumonia.In addition to the above situations, azithromycin is also a commonly used drug for preventing rheumatic fever. If used strictly under the guidance of a doctor, it can also be combined with dexamethasone acetate preparations to effectively inhibit the disease. It can also be used for simple genital infections caused by non multidrug-resistant Neisseria gonorrhoeae, as well as diseases such as chancre caused by Haemophilus duke.However, it should be noted that if one is allergic to azithromycin, erythromycin, and other macrolide drugs, their use should be prohibited. Individuals with a history of cholestatic jaundice and liver dysfunction should not use this medication. Pregnant women and lactating women should strictly follow medical advice and use medication with caution to avoid affecting the fetus or baby.